Beilstein J. Org. Chem.2011,7, 1182–1188, doi:10.3762/bjoc.7.137
Abhishek Santra Anup Kumar Misra Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata-700054, India; Fax: 91-33-2355 3886 10.3762/bjoc.7.137 Abstract A convenient synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigellaboydii type 9 has been
glycoside in high yield.
Keywords: diarrhea; glycosylation; O-antigen; oligosaccharide; Shigellaboydii; Introduction
Diarrhoeal disease is a common cause of death in the tropical countries and it is the second mostly causing infant deaths worldwide. Shigella is one of the well-studied human pathogens
that cause diarrhoeal disease and dysentery (e.g., shigellosis). Among several types of Shigella species, Shigella dysenteriae is the most virulent pathogen causing devastating health problems in developing countries [1][2][3]. Shigella strains are classified into four species: Shigellaboydii
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Graphical Abstract
Figure 1:
Structure of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9.